A Comprehensive Review on Floating Drug Delivery System (FDDS)

Abstract

Floating Drug Delivery Systems (FDDS) represent a promising approach for the controlled release of drugs, particularly for drugs that have a narrow absorption window in the gastrointestinal tract. These systems are designed to float in the stomach, offering sustained drug release and improving bioavailability. FDDS ensure a prolonged gastric residence time (GRT), which allows for more efficient drug absorption. This review explores the design, mechanisms, applications, and challenges of FDDS, as well as various formulation strategies, such as the use of hydrocolloids, gas-generating agents, and low-density materials to enhance buoyancy. The article highlights the recent advancements in FDDS technology, emphasizing its potential to improve therapeutic efficacy and patient compliance, especially for drugs with specific absorption sites.